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Desogestrel


Drug Approvals

(British Approved Name, US Adopted Name, rINN)

INNs in other languages (French, Latin, and Spanish): Desogestreeli; Desogestrel; Desogestrelum; Dezogestrel; Org-2969.

13β-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol.

C22H30O = 310.5.

CAS 54024-22-5.

ATC G03AC09.

Pharmacopoeias. In Europe.

European Pharmacopoeia, 6th ed. (Desogestrel). A white or almost white, crystalline powder. Practically insoluble in water freely soluble in dehydrated alcohol and in dichloromethane very soluble in methyl alcohol.

Adverse Effects and Precautions

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives. When used as a progestogen-only contraceptive, irregular bleeding is more common with desogestrel than with other progestogen-only preparations. Desogestrel is reported to have few androgenic effects, and to have less adverse effect on the serum lipid profile than older 19-nortestosterone derivatives. However, there is some evidence that desogestrel-con-taining combined oral contraceptives are associated with a small increased risk of venous thromboembolism.

Interactions

As for progestogens in general (see Progesterone). See also under Hormonal Contraceptives.

Pharmacokinetics

After oral doses, desogestrel undergoes oxidative transformation in the intestinal mucosa and liver to its active metabolite 3-keto-desogestrel (etonogestrel).

Uses and Administration

Desogestrel is a progestogen (see Progesterone) structurally related to levonorgestrel that is used as a hormonal contraceptive. A typical daily dose of 150 micrograms is used as the pro-gestogenic component of monophasic combined oral contraceptive preparations. Doses of 50 to 150 micrograms daily may be used in triphasic combined preparations. A dose of 75 micrograms daily is used as an oral progestogen-only contraceptive unlike traditional progestogen-only contraceptives, desogestrel is said to reliably inhibit ovulation. Progestogen-only contraceptive efficacy is reduced if a dose of desogestrel is delayed by more than 12 hours.

Contraception. The effects of a progestogen-only contraceptive containing desogestrel have been reported. Oral desogestrel has also been investigated as a male contraceptive, combined with testosterone given by intramuscular injection, subcutaneous implant, or transdermal patch.

Preparations

The United States Pharmacopeia 31, 2008: Desogestrel and Ethinyl Estradiol Tablets.

Proprietary Preparations

Argentina: Cerazette

Austria: Cerazette

Belgium: Cerazette

Brazil: Cerazette Kelly

Chile: Arlette Cerazette Nogesta Vanish

Czech Republic: Azalia Cerazette

Denmark: Cerazette

Finland: Cerazette

France: Cerazette

Germany: Cerazette

Greece: Cerazette

Hungary: Cerazette

Indonesia: Cerazette

Israel: Cerazette

Italy: Cerazette

Mexico: Cerazette

The Netherlands: Cerazette

Norway: Cerazette

New Zealand: Cerazette

Philippines: Cerazette

Poland: Cerazette

Portugal: Cerazette

Russia: Cerazette (Haposeira)

Spain: Cerazet

Sweden: Cerazette

Switzerland: Cerazette

UK: Cerazette

Venezuela: Arlette Cerazette.

Multi-ingredient:

Argentina: Marvelon Mercilon

Australia: Marvelon

Austria: Gracial Laurina Liberel Lisetaf Marvelon Mercilon

Belgium: Desorelle Gracial Marvelon Mercilon Ovidol

Brazil: Femina Gestradiol Gracial Malu Mercilon Mercilon Conti Microdiol Minian Novial Primera

Canada: Marvelon Ortho-Cept

Chile: Ciclidon Dal Desoren Gracial Gynostat Marvelon Midalet Miniestrel Neolette

Czech Republic: Gracial Jenettenf Laurina Marvelon Mercilon Novynette Regulon Vilonet

Denmark: Desorelle Gracial Marvelon Mercilon Novynette

Finland: Gracial Marvelon Mercilon

France: Cycleane Mercilon Varnoline

Germany: Biviol Cyclosa Desmin Lamuna Lovelle Marvelon Novial Oviol

Greece: Gracial Laurina Marvelon Mercilon

Hong Kong: Gracial Marvelon Mercilon Novynette

Hungary: Gracial Marvelon Mercilon Novynette Regulon

India: Femilon Novelon

Indonesia: Marvelon Mercilon

Ireland: Marviol Mercilon

Israel: Feminet Mercilon Microdiol

Italy: Dueva Gracial Mercilon Planum Practil Securgin

Malaysia: Marvelon Mercilon Novynette Regulon

Mexico: Marvelon Mercilon Novial

The Netherlands: Gracial Marvelon Mercilon Ovidol

Norway: Marvelon

New Zealand: Marvelon Mercilon Trimiron

Philippines: Gracial Marvelon Mercilon

Poland: Marvelon Mercilon Novynette Regulon

Portugal: Gracial Laurina Marvelon Mercilon Novynette Regulon

Russia: Marvelon Mercilon Novynette Regulon Tri-Merci

South Africa: Marvelon Mercilon

Singapore: Marvelon Mercilon

Spain: Gracial Microdiol Suavuret

Sweden: Desolett Mercilon Trimiron

Switzerland: Gracial Marvelon Mercilon

Thailand: Marvelon Mercilon Oilezz

Turkey: Desolett Myralon

UK: Marvelon Mercilon

USA: Apri Cesia Cyclessa Desogen Kariva Mircette Ortho-Cept Reclipsen Solia Velivet

Venezuela: Ciclidon Marvelon Mercilon Mipil Novial.

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