Drugs

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

How many of your patients chronically take non-steroidal anti-inflammatory drugs (NSAIDs)? In a recent Saskatchewan survey, approximately 13% of the general population had filled a prescription for an NSAID during the preceding year. In British Columbia these drugs…

Non-steroidal Anti-inflammatory Drugs: Gastrointestinal Effects

The gastrointestinal effects of non-steroidal anti-inflammatory drugs range from dyspepsia to gastric ulceration, hemorrhage, and perforation. Minor symptoms of gastrointestinal discomfort are reported in 10% to 40% of patients using non-steroidal anti-inflammatory drugs. Gastric ulcers occur in up…

Safe Handling of Chemotherapeutic Agents

Occupational exposure to hazardous drugs and the resulting potential health risk to healthcare workers first became a recognized safety concern in the 1970s. Published data related to the issue of occupational exposure prompted the Occupational Safety and Health…

Opioid overdose: Class

Morphine, the prototype opioid, is derived from opium, a crude material obtained from the seed pod of the opium poppy plant. The chemical structure of morphine is shown in Figure Structure-activity relationships of opioids. Many other derivatives of…

Psychotropic Drugs in Children: Imipramine (Tofranil)

Table 3. Prescribing Information for Imipramine (Tofranil ®) Optimum Dosage Usual maximum 5 mg/kg/day Enuresis: 0-6 yr — not indicated 6-12 yr — up to 50 mg/day 12+ — up to 75 mg/day ADD with anxiety or depression:…

Adverse Drug Reactions

Introduction Most general practitioners (GPs) will be familiar with the sometimes perplexing problem of trying to decide whether a patient’s symptom is owing to an adverse drug reaction, to a symptom of the presenting illness, or to an…

Pharmaceutical care in the older patient

Medications are probably the single most important healthcare technology in preventing illness, disability, and death in the geriatric population. New products provide pharmacists with valuable tools for promoting quality of life but also confer upon them the more…

Psychotropic Drugs in Children: Dose and Administration

In general, prescription should begin at the lowest dosage. Give an adequate trial at each succeeding dosage level. Recognize that stimulants show an effect within hours, tranquilizers within days, and antidepressants sometimes not for weeks. Therapeutic blood levels…

Requip Relieves Restless Legs

Significant improvement found in patients with RLS. The first double-blind, placebo-controlled study of Requip in patients with restless legs syndrome (RLS) showed the drug led to significant improvement in the periodic leg movements (PLMS) of sleep. The primary…

Medications that Zap Your Cholesterol

Talk to your pharmacist! Cholesterol and its Role in the Body Cholesterol is a type of fat, which we need in our diet to help us build cells in our body and make hormones, which act as chemical…