Cardiovasculars

Statins Cut Risk of Stroke

By lowering cholesterol, drug reduces stroke events. By analyzing 28 studies involving use of HMGcoA reductase inhibitors or other anti-lipidemic agents in more than 100,000 patients, researchers have concluded that those patients given the HMGcoA inhibitors were 0.76…

Counseling on Colesevelam (Welchol) Part 3

Adverse Reactions In clinical trials, all doses of colesevelam were generally well tolerated. Colesevelam is not absorbed in the digestive tract, reducing the potential for systemic adverse side effects. Also, its water-retaining ability creates a soft, gelatinous material…

Counseling on Colesevelam (Welchol) Part 2

Pharmacology and Pharmacokinetics Bile acids are formed from cholesterol in a series of reactions regulated by the enzyme 7-alpha- hydroxylase. During normal digestion, bile acids are secreted into the intestine. A major portion of bile acids are then…

Counseling on Colesevelam (Welchol) Part 1

What does the pharmacist need to know to counsel patients about colesevelam? Development Epidemiological studies have established that elevated levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipo-protein B (Apo B), as well as decreased levels of HDL-cholesterol…