Antiepileptics

Med Trileptal: Another Choice for Partial Onset Epilepsy

Brand Name: Trileptal Active Ingredient: oxcarbazepine Indication: Treatment of partial epileptic seizures as monotherapy in adults or adjunctive therapy in adults and children as young as age 4 Company Name: Novartis Pharmaceuticals Corporation Availability: Approved by FDA January…

Cognitive side-effects due to antiepileptic drug combinations and interactions

The possibility that cognitive impairment may develop as a consequence or aftermath of epilepsy was raised as early as 1885 when Gowers described ‘epileptic dementia’ as an effect of the pathological sequela of seizures. Nonetheless, the topic was…

Topiramate (Topamax) and epilepsy

Epilepsy is a group of disorders of the brain characterized by recurring episodes of convulsive seizures, sensory disturbances, abnormal behaviour, loss of consciousness, or all of these. In all types of epilepsy, an uncontrolled electrical discharge from the…

Clinical effects

Although the psychometric studies generally show a tendency of cognitive impairments in polytherapy compared to monotherapy, this merely suggests a drug interaction effect. As previously mentioned evidence-based confirmation will be extremely difficult due to the methodological problems that…

Med Topiramate (Topamax) in Epilepsy

The FDA has approved a novel antiepileptic agent – topiramate (Topamax/Ortho-McNeil)-for the adjunctive treatment of adults with partial-onset seizures. Topiramate was identified by scientists at the National Institutes of Health during random screening of promising drug candidates, and…

Drug interactions: OCs, AEDs, and the risk of pregnancy

Studies have shown that the most commonly used antiepileptic drugs (AEDs) reduce blood levels of oral contraceptives (OCs) by about 40%. But how many physicians know this? After seeing five epileptic patients in two years at Johns Hopkins…