Antiepileptics

Parenteral fosphenytoin, diazepam rectal gel for refractory seizures, status epilepticus

Status epilepticus is a persistent, generalized tonic-clonic seizure that occurs in some 60,000 Americans each year, primarily children but also frequently people over age 60. One third of patients are known epileptics and one third have no history…

Carbamazepine

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Carbamazepina; Carbamazepinum; G–32883; Karbamatsepiini; Karbamazepin; Karbamazepinas BAN: Carbamazepine USAN: Carbamazepine INN: Carbamazepine [rINN (en)] INN: Carbamazepina…

Antiepileptics – Question – Answer

Question. How many double blind studies have been done on the use of antiepileptics for rapid cyclers? If anxiety is a factor, what other drugs should be used with them? Answer. There are now four main anticonvulsant (anti-epileptic)…

Drug Zonegran for Epilepsy

Brand Name: Zonegran Active Ingredient: zonisamide Indication: Adjunctive therapy in the treatment of partial seizures in adults with epilepsy Company Name: Elan Corporation, plc Availability: Approved by FDA on March 28, 2000; Zonegran has been marketed under the…

Clobazam

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Clobazamum; H-4723; HR-376; Klobatsaami; Klobazam; Klobazamas; LM-2717 BAN: Clobazam USAN: Clobazam INN: Clobazam [rINN (en)] INN:…

Review of psychometric studies

The interest in the cognitive side-effects of antiepileptic drug treatment is of relatively recent origin and the first studies are from the 1970s,probably stimulated bythe widening range of possibilities for drug treatment during that period; valproate and carbamazepine…

Med Trileptal: Another Choice for Partial Onset Epilepsy

Brand Name: Trileptal Active Ingredient: oxcarbazepine Indication: Treatment of partial epileptic seizures as monotherapy in adults or adjunctive therapy in adults and children as young as age 4 Company Name: Novartis Pharmaceuticals Corporation Availability: Approved by FDA January…

Cognitive side-effects due to antiepileptic drug combinations and interactions

The possibility that cognitive impairment may develop as a consequence or aftermath of epilepsy was raised as early as 1885 when Gowers described ‘epileptic dementia’ as an effect of the pathological sequela of seizures. Nonetheless, the topic was…

Topiramate (Topamax) and epilepsy

Epilepsy is a group of disorders of the brain characterized by recurring episodes of convulsive seizures, sensory disturbances, abnormal behaviour, loss of consciousness, or all of these. In all types of epilepsy, an uncontrolled electrical discharge from the…

Clinical effects

Although the psychometric studies generally show a tendency of cognitive impairments in polytherapy compared to monotherapy, this merely suggests a drug interaction effect. As previously mentioned evidence-based confirmation will be extremely difficult due to the methodological problems that…